mBio 8(5) e00845-17. J. Virol. Gunn, A.L. Ward, A. W. Rimoin, A. Bukreyev*, and J. E. Crowe, Jr*. Antibody repertoires to the same Ebola vaccine antigen are differentially affected by vaccine vectors. Ph ILINYKH of University of Texas Medical Branch at Galveston, Texas (UTMB) | Read 72 publications | Contact Ph ILINYKH Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection. (2016). C. Le Nouën, P. Hillyer, S. Munir, C. C Winter, T. McCarty, A. Bukreyev, P. L Collins, R. L Rabin, and U. J Buchholz (2010). The article was chosen for UTMB and the Vanderbilt University press releases on 5/26/2015. Genome sequencing of emerging viral pathogens, including paramyxoviruses and filoviruses. Cell 164(3): 392-405. 5): S475-S485. In 2017-2018, UTMB CLS graduates earned 100% ASCP Board of Certification one-year pass rate. Topoisomerase II inhibitors induce DNA Damage dependent interferon responses circumventing Ebola virus immune evasion. Effect of co-expression of IL-2 by recombinant respiratory syncytial virus on virus replication, immunogenicity and production of other cytokines. J. Virol. J. Harker, A. Bukreyev, P. Collins, B. Wang, J. S. Tregoning, and P. J. M. Openshaw (2007). Cell Reports 24: 1816-1829. J. J. Infect. J. Virol. The Master of Science degree in Clinical Laboratory Science (MSCLS) in the School of Health Professions is designed to prepare the clinical laboratory scientist for a career in research, teaching or management within clinical laboratory medicine. Effects of human respiratory syncytial virus, metapneumovirus, paramyxovirus type 3, and influenza A virus on the ability of human dendritic cells to activate autologous CD4 T cells. Cell Reports 24: 1802-1815. Neutralizing antibodies from human survivors target a conserved site in the ebolavirus glycoprotein HR2/MPER regions. P. Luthra, S. Aguirre, M. T. Sanchez, B. C. Yen, C. A. Pietzsch, B. Tigabu, L. Morlock, A. Garcia-Sastre, A. Sesma, N. Williams, A. Bukreyev, D. W. Leung, and C. Basler. Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors. The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains. (2019) Modified mRNA-based vaccines elicit robust immune responses and protect guinea pigs from Ebola virus disease. Kang's Lab At Utmb is on Facebook. King, B. R. West, C. L. Moyer, P. Gilchuk, A. Flyak, P. A. Ilinykh, R. Bombardi, S. Hui, K. Huang, A. Bukreyev, J. E. Crowe, Jr. and E. Ollmann Saphire (2019). P. A. Ilinykh, J. Graber, N. A. Kuzmina, K. Huang, T. G. Ksiazek, J. E. Crowe, Jr. and A. Bukreyev (2018). G. Liu, P. Nash, B. Johnson, C. Pietzsch, M. Ilagan, A. Bukreyev, C. Basler, T. Bowlin, D. Moir, D. Leung, and G. Amarasinghe. Journal of Infectious Diseases 218 (Suppl. The article was chosen for UTMB and the Vanderbilt University press releases on 1/21/2016, and was highlighted in Nature 529, 440. Successful topical respiratory tract immunization of primates against Ebola virus. Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody. In: Advances in virus research, 54:423-451. A. Kotelkin, I. M. Belyakov, L. Yang, J. Bukreyev is the lead investigator of the funded studies conducted at UTMB. S. S. Whitehead, A. Bukreyev, M. N. Teng, C.-Y. Acad. The UTMB Department of Clinical Laboratory Sciences has the career path for you. Ward, E. O. Saphire, A. Bukreyev*, and J. E. Crowe, Jr.* (2015) Mechanism of human antibody-mediated neutralization of Marburg virus. 5): S418-S422. Our Lab focuses on investigation of the mechanisms of the high pathogenicity of viruses Ebola, Marburg and Lassa and development of vaccines and antibody treatments against these viruses. 86(19):10880-10884. ICTV, Viruses, in press. Individuals interested in joining the lab as a Research Associate, a Postdoctoral Fellow or a Research Scientist should send a brief email and CV or resume directly to Dr. Bukreyev. Cross-reactive, neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Cell 164(3): 392-405. A. I. Flyak, P. A. Ilinykh, C. D. Murin, T. Garron, X. Shen, M. L. Fusco, T. Hashiguchi, Z. Natl. J. Virol. B. 217(2):451-455. Cell 160(5) 893-903. Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 and its targeting for the inhibition of viral transcription. Z. Wec, C. L. Moyer, M. L. Fusco, P. A. Ilinykh, K. Huang, A. S. Wirchnianski, R. M. James, A. S. Herbert, S. Hui, E. Goodwin, K. A. Howell, S. Kailasan, M. J. Aman, L. M. Walker, J. M. Dye, A. Bukreyev, K. Chandran and E. Ollmann Saphire (2019). Journal of Infectious Diseases 218(Suppl. (2018). B. Non-structural proteins 1 and 2 of respiratory syncytial virus suppress maturation of human dendritic cells. B. Tigabu, P. Ramanathan, A. Ivanov, X. Lin, P. A. Ilinykh, C. S. Parry, A. N. Freiberg, S. Nekhai and A. Bukreyev (2018). The HPIV3-vectored intranasal vaccine against Ebola virus is immunogenic in HPIV3-immune animals. M. Meyer, A. Yoshida, P. Ramanathan, E. Ollmann Saphire, P. Collins, J. E. Crowe Jr., S. Samal and A. Bukreyev (2018). Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. Antibody-mediated protective mechanisms induced by a trivalent parainfluenza-vectored ebolavirus vaccine. Taxonomy of the order Mononegavirales: Update 2017. L. Zhang, A. Bukreyev, C. Thompson, B. Watson, M. E. Peeples, P. L Collins, and R. J. Pickles (2005). Mucosal immunization protects monkeys against SARS coronavirus infection. Natl. *Co-corresponding author. Dr. Alex Bukreyev at the University of Texas Medical Branch and the Galveston National Laboratory reports, “Our lab tested a panel of antibodies against a real SARS-CoV-2 in biocontainment. Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection. Disabling of lymphocyte immune response by Ebola Virus. Mire, P.A. The article was chosen for American Society for Microbiology press release in November 2007. H. Bisht, A. Roberts, L. Vogel, A. Bukreyev, P. Collins, B. Murphy, K. Subbarao, and B. Moss (2004). (2018). The Ebola interferon inhibiting domains attenuate and dysregulate cell-mediated immune responses. Journal of Infectious Diseases 218 (Suppl. PLOS Pathogens 14(8):e1007204. Natl. A. Bukreyev, I. M. Belyakov, G. A. Neutralizing antibodies from human survivors target a conserved site in the ebolavirus glycoprotein HR2/MPER regions. A. Berzofsky, B. R. Murphy and P. L. Collins (2001). Vodzak, S. Li, A. Okoli, M. 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